Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases.
However, its therapeutic applications are limited by unintended genomic alterations arising …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

Chromatin mobility is thought to facilitate homology search during homologous
recombination and to shift damage either towards or away from specialized repair …

A DNA double-strand break (DSB) has long been recognized as a severe cellular lesion,
potentially representing an initiating event for carcinogenesis or cell death. The evolution of …