Transition-metal-catalyzed C–H bond activation for the formation of C–C bonds in complex molecules
Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …
powerful strategies for the step-economic diversification of both feedstock and fine …
Electrochemical late-stage functionalization
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …
diversification of novel molecular entities with improved physicochemical or biological …
Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds
Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …
revolutionized synthetic planning over the past few decades as the use of these directing …
Toolbox for distal C–H bond functionalizations in organic molecules
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
C–H activation
T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
3d transition metals for C–H activation
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …
notable applications to material sciences, crop protection, drug discovery, and …
Late‐stage peptide diversification by position‐selective C− H activation
The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
Late‐stage C− H Functionalization of Tryptophan‐Containing Peptides with Thianthrenium Salts: Conjugation and Ligation
N Kaplaneris, A Puet, F Kallert… - Angewandte Chemie …, 2023 - Wiley Online Library
Bioorthogonal late‐stage diversification of structurally complex peptides bears enormous
potential for drug discovery and molecular imaging, among other applications. Herein, we …
potential for drug discovery and molecular imaging, among other applications. Herein, we …
Visible‐Light‐Promoted C(sp3)−H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α‐Amino Acids and Late‐Stage Modification of Peptides
C Wang, R Qi, H Xue, Y Shen, M Chang… - Angewandte …, 2020 - Wiley Online Library
Disclosed herein is the visible‐light‐promoted deaminative C (sp3)− H alkylation of glycine
and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent …
and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent …