Recent advancement in therapeutic strategies for Alzheimer's disease: insights from clinical trials

T Khan, R Waseem, M Shahid, J Ansari… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …

Understanding the Modulation of α-Synuclein Fibrillation by N-Acetyl Aspartate: A Brain Metabolite

T Khan, R Waseem, M Shahid, J Ansari, MI Hassan… - ACS …, 2024 - ACS Publications
α-Synuclein (α-Syn) fibrillation is a prominent contributor to neuronal deterioration and plays
a significant role in the advancement of Parkinson's Disease (PD). Considering this, the …

Aggregation of irisin and its prevention by trehalose: A biophysical approach

R Waseem, D Yameen, T Khan, A Anwer… - Journal of Molecular …, 2023 - Elsevier
During the last two decades, protein misfolding and aggregation has become one of the
most competitive and challenging research problems, which underlies a broad range of …

Molecular basis of structural stability of Irisin: A combined molecular dynamics simulation and in vitro studies for Urea-induced denaturation

R Waseem, NS Yadav, T Khan, F Ahmad… - Journal of Molecular …, 2023 - Elsevier
Irisin is a recently discovered myokine having important role in adipose tissue metabolism,
neuronal functioning as well as bone metabolism. In this study, urea-induced denaturation …

Inhibitory potential of N-acetylaspartate against protein glycation, AGEs formation and aggregation: Implication of brain osmolyte in glycation-related complications

R Waseem, T Khan, A Shamsi, M Shahid… - International Journal of …, 2023 - Elsevier
Protein glycation and aggregation have a pivotal role in many diseases including diabetes
and neurodegenerative disorders. N-acetyl aspartate (NAA), an osmolyte derived from L …

In vitro antifungal activity, cytotoxicity and binding analysis of imidazolium based ionic liquids with fluconazole: DFT and spectroscopic study

Y Kumar, FA Wani, S Ahmedi, A Shamsi… - Journal of Molecular …, 2024 - Elsevier
Fungal infections represent a significant challenge in various living organisms, including
humans, animals, and plants. Fungi are versatile organisms capable of thriving in diverse …

Identification of defactinib derivatives targeting focal adhesion kinase using ensemble docking, molecular dynamics simulations and binding free energy calculations

C Guo, Q Li, J Xiao, F Ma, X Xia… - Journal of Biomolecular …, 2023 - Taylor & Francis
Focal adhesion kinase (FAK) belongs to the nonreceptor tyrosine kinases, which selectively
phosphorylate tyrosine residues on substrate proteins. FAK is associated with bladder …

[HTML][HTML] Comment on Budryn et al. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients 2022, 14, 2476

I Zarguan, A Benjouad, L Belayachi - Nutrients, 2022 - mdpi.com
Nutrients | Free Full-Text | Comment on Budryn et al. Hydroxybenzoic Acids as
Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients 2022, 14 …

[HTML][HTML] Effect of Fluoxetine on Post-Hysterectomy Nursing of Patients with Endometrial Cancer: A Retrospective Study

N Sun, W Yan, L Wang, J Wang… - Clinical and Experimental …, 2023 - imrpress.com
Background: The incidence and mortality of endometrial cancer (EC) have increased in
recent years. The incidence of psychological disorders induced by EC is also increasing …

Targeting beta-amyloid plaques and neurofibrillary tangles: a proteomic approach towards Alzheimer's disease therapy

S Kashif, S Feroze, AA Sethi - International Journal of Biology and …, 2024 - ijbch.kaznu.kz
Alzheimer's disease (AD) stands as the most prevalent form of dementia affecting elderly
individuals and ranks as the sixth leading cause of death globally. The pathological …