Recent advancement in therapeutic strategies for Alzheimer's disease: insights from clinical trials
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …
Understanding the Modulation of α-Synuclein Fibrillation by N-Acetyl Aspartate: A Brain Metabolite
α-Synuclein (α-Syn) fibrillation is a prominent contributor to neuronal deterioration and plays
a significant role in the advancement of Parkinson's Disease (PD). Considering this, the …
a significant role in the advancement of Parkinson's Disease (PD). Considering this, the …
Aggregation of irisin and its prevention by trehalose: A biophysical approach
During the last two decades, protein misfolding and aggregation has become one of the
most competitive and challenging research problems, which underlies a broad range of …
most competitive and challenging research problems, which underlies a broad range of …
Molecular basis of structural stability of Irisin: A combined molecular dynamics simulation and in vitro studies for Urea-induced denaturation
Irisin is a recently discovered myokine having important role in adipose tissue metabolism,
neuronal functioning as well as bone metabolism. In this study, urea-induced denaturation …
neuronal functioning as well as bone metabolism. In this study, urea-induced denaturation …
Inhibitory potential of N-acetylaspartate against protein glycation, AGEs formation and aggregation: Implication of brain osmolyte in glycation-related complications
Protein glycation and aggregation have a pivotal role in many diseases including diabetes
and neurodegenerative disorders. N-acetyl aspartate (NAA), an osmolyte derived from L …
and neurodegenerative disorders. N-acetyl aspartate (NAA), an osmolyte derived from L …
In vitro antifungal activity, cytotoxicity and binding analysis of imidazolium based ionic liquids with fluconazole: DFT and spectroscopic study
Fungal infections represent a significant challenge in various living organisms, including
humans, animals, and plants. Fungi are versatile organisms capable of thriving in diverse …
humans, animals, and plants. Fungi are versatile organisms capable of thriving in diverse …
Identification of defactinib derivatives targeting focal adhesion kinase using ensemble docking, molecular dynamics simulations and binding free energy calculations
C Guo, Q Li, J Xiao, F Ma, X Xia… - Journal of Biomolecular …, 2023 - Taylor & Francis
Focal adhesion kinase (FAK) belongs to the nonreceptor tyrosine kinases, which selectively
phosphorylate tyrosine residues on substrate proteins. FAK is associated with bladder …
phosphorylate tyrosine residues on substrate proteins. FAK is associated with bladder …
[HTML][HTML] Comment on Budryn et al. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients 2022, 14, 2476
I Zarguan, A Benjouad, L Belayachi - Nutrients, 2022 - mdpi.com
Nutrients | Free Full-Text | Comment on Budryn et al. Hydroxybenzoic Acids as
Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients 2022, 14 …
Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients 2022, 14 …
[HTML][HTML] Effect of Fluoxetine on Post-Hysterectomy Nursing of Patients with Endometrial Cancer: A Retrospective Study
N Sun, W Yan, L Wang, J Wang… - Clinical and Experimental …, 2023 - imrpress.com
Background: The incidence and mortality of endometrial cancer (EC) have increased in
recent years. The incidence of psychological disorders induced by EC is also increasing …
recent years. The incidence of psychological disorders induced by EC is also increasing …
Targeting beta-amyloid plaques and neurofibrillary tangles: a proteomic approach towards Alzheimer's disease therapy
Alzheimer's disease (AD) stands as the most prevalent form of dementia affecting elderly
individuals and ranks as the sixth leading cause of death globally. The pathological …
individuals and ranks as the sixth leading cause of death globally. The pathological …