CtBP family proteins are conserved among vertebrates and invertebrates and function as
transcriptional corepressors. They repress transcription in a histone deacetylase-dependent …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …

In the S and G2 phases of the cell cycle, DNA double-strand breaks (DSBs) are processed
into single-stranded DNA, triggering ATR-dependent checkpoint signalling and DSB repair …

Chromosomal rearrangements including large DNA-fragment inversions, deletions, and
duplications by Cas9 with paired sgRNAs are important to investigate genome structural …

In G 0 and G 1, DNA double strand breaks are repaired by nonhomologous end joining,
whereas in S and G 2, they are also repaired by homologous recombination. The human …

BRCA1 plays an important role in the homologous recombination (HR)-mediated DNA
double-strand break (DSB) repair, but the mechanism is not clear. Here we describe that …

Maintenance of genome stability depends on efficient, accurate repair of DNA damage. DNA
double-strand breaks (DSBs) are among the most lethal types of DNA damage, with the …

Transcriptional repression is based on the selective actions of recruited corepressor
complexes, including those with enzymatic activities. One well-characterized …

In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate
with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand …

Background and aims: Ovarian cancer (OC) is the seventh most commonly detected cancer
among women. This study aimed to map the hub and core genes and potential pathways …