Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function
within changing cellular environments. Changes in the mechanical environment, ranging …
within changing cellular environments. Changes in the mechanical environment, ranging …
The LINC between mechanical forces and chromatin
O Lityagina, G Dobreva - Frontiers in Physiology, 2021 - frontiersin.org
The heart continually senses and responds to mechanical stimuli that balance cardiac
structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the …
structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the …
[HTML][HTML] Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart
DJ Chapski, M Cabaj, M Morselli, RJ Mason… - Journal of molecular and …, 2021 - Elsevier
The temporal nature of chromatin structural changes underpinning pathologic transcription
are poorly understood. We measured chromatin accessibility and DNA methylation to study …
are poorly understood. We measured chromatin accessibility and DNA methylation to study …
Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes
M Hesse, R Bednarz, E Carls, C Becker… - Journal of Molecular and …, 2021 - Elsevier
The adult mammalian heart consists of mononuclear and binuclear cardiomyocytes (CMs)
with various ploidies. However, it remains unclear whether a variation in ploidy or number of …
with various ploidies. However, it remains unclear whether a variation in ploidy or number of …
DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization
PJ Stanczyk, Y Tatekoshi, JS Shapiro, K Nayudu… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: Proper nuclear organization is critical for cardiomyocyte function, because
global structural remodeling of nuclear morphology and chromatin structure underpins the …
global structural remodeling of nuclear morphology and chromatin structure underpins the …
Three-dimensional chromatin organization in cardiac development and disease
A Bertero, M Rosa-Garrido - Journal of molecular and cellular cardiology, 2021 - Elsevier
Recent technological advancements in the field of chromatin biology have rewritten the
textbook on nuclear organization. We now appreciate that the folding of chromatin in the …
textbook on nuclear organization. We now appreciate that the folding of chromatin in the …
RNA biogenesis instructs functional inter-chromosomal genome architecture
A Bertero - Frontiers in Genetics, 2021 - frontiersin.org
Three-dimensional (3D) genome organization has emerged as an important layer of gene
regulation in development and disease. The functional properties of chromatin folding within …
regulation in development and disease. The functional properties of chromatin folding within …
The counterpart congenital overgrowth syndromes Beckwith-Wiedemann Syndrome in human and large offspring syndrome in bovine involve alternations in DNA …
Abstract Beckwith-Wiedemann Syndrome (BWS, OMIM# 130650) is a congenital epigenetic
disorder in humans which affects approximately 1 in 10,340 children. The incidence is likely …
disorder in humans which affects approximately 1 in 10,340 children. The incidence is likely …
Single-cell transcriptomes in the heart: when every epigenome counts
T Gromova, ND Gehred… - Cardiovascular …, 2023 - academic.oup.com
The response of an organ to stimuli emerges from the actions of individual cells. Recent
cardiac single-cell RNA-sequencing studies of development, injury, and reprogramming …
cardiac single-cell RNA-sequencing studies of development, injury, and reprogramming …
Single-cell transcriptomes in the heart: when every epigenome counts.
T Gromova, ND Gehred… - Cardiovascular Research, 2023 - escholarship.org
The response of an organ to stimuli emerges from the actions of individual cells. Recent
cardiac single-cell RNA-sequencing studies of development, injury, and reprogramming …
cardiac single-cell RNA-sequencing studies of development, injury, and reprogramming …