Abstract β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red
blood cell transfusions and iron chelation therapy to prevent complications due to iron …

Abstract Hemoglobin (Hb) Bart's hydrops fetalis syndrome (BHFS) resulting from α0-
thalassemia is considered a universally fatal disorder. However, over the last 3 decades …

Alpha thalassemia major (ATM) is a hemoglobinopathy that usually results in perinatal
demise if in utero transfusions (IUTs) are not performed. We established an international …

Hemoglobin Bart's hydrops fetalis syndrome (BHFS) represents the most severe form of α-
thalassemia, arising from deletion of the duplicated α-globin genes from both alleles. The …

Introduction: Carrier screening for recessive disorders is undertaken by prospective parents
to inform their reproductive decisions. With the growing availability of affordable and …

Objective Alpha thalassemia major (ATM) is often fatal in utero due to severe hydrops fetalis.
Although in utero transfusions (IUTs) are increasingly used to allow fetal survival in ATM …

Objectives To identify procedural risk factors associated with fetal loss following
cordocentesis and to determine the rate of cordocentesis‐related fetal loss associated with …

Purpose Current practice recommendations support the widespread implementation of
reproductive genetic carrier screening (RGCS). These consensus-based recommendations …

1Department of Surgery, 2Department of Obstetrics and Gynecology, 3Department of
Pediatrics and Benioff Children's Hospital, and 4Center for Maternal-Fetal Precision …

Children and adolescents with thalassemia suffer from chronicity of the disease and its
treatment, including transfusion dependence and complications of iron overload. This study …