A critical event in ischemia-based cell death is the opening of the mitochondrial permeability
transition pore (MPTP). However, the molecular identity of the components of the MPTP …

Cell death is a common and important feature of animal development, and cell death defects
underlie many human disease states. The nematode Caenorhabditis elegans has proven …

In C. elegans, the BH3-only domain protein EGL-1, the Apaf-1 homolog CED-4 and the CED-
3 caspase are required for apoptosis induction, whereas the Bcl-2 homolog CED-9 prevents …

Every lipid membrane fission event involves the association of two apposing bilayers,
mediated by proteins that can promote membrane curvature, fusion and fission. We tested …

Proteins belonging to Bcl‐2 family regulate intrinsic cell death pathway. Although
mammalian antiapoptotic Bcl‐2 members interact with multiple proapoptotic proteins, the …

Programmed cell death is a critical process that is necessary to cull damaged cells as well
as eliminate unnecessary cells during normal development. Improper regulation of this …

The formation and maintenance of tissues and organs mandate a fine-tuned balance
between cell proliferation and cell loss. Apoptosis as one form of programmed cell death …

Cell death is a major cell fate that promotes tissue sculpting and morphogenesis during
animal development. Many developmental cell-culling events cannot be accounted for …

The BCL-2 family proteins are crucial regulators of the apoptotic process. This book covers
recent structure-based insights into the mechanisms of action of antiapoptotic BCL-2 family …

Mitochondria have complex morphologies thought to be derived from a balance of fission
and fusion events. However, despite their importance to cellular homeostasis, cell death …