Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

Nucleoli form around tandem arrays of a ribosomal gene repeat, termed nucleolar organizer
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

In eukaryotes, the genes encoding ribosomal RNAs (rDNA) exist in two distinct epigenetic
states that can be distinguished by a specific chromatin structure that is maintained …

For over 100 years, pathologists have utilised an increase in size and number of nucleoli,
the subnuclear site of ribosome synthesis, as a marker of aggressive tumours. Despite this …

The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and
leukemia. RUNX1 mutations can be early events, creating preleukemic stem cells that …

On entry into mitosis, many transcription factors dissociate from chromatin, resulting in global
transcriptional shutdown. During mitosis, some genes are marked to ensure the inheritance …

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly
metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in …

While most transcription factors exit the chromatin during mitosis and the genome becomes
silent, a subset of factors remains and “bookmarks” genes for rapid reactivation as cells …