Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular
biology has been extensively studied resulting in identification of a complex nature of …

Autophagy is a major protein degradation pathway capable of upholding cellular
metabolism under nutrient limiting conditions, making it a valuable resource to highly …

Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC
inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However …

Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline
antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the …

Dysregulation of the balance between cell proliferation and cell death is a central feature of
malignances. Death-associated protein kinase 3 (DAPK3) regulates programmed cell death …

Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in
the AMP: ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in …

Aging is a universal phenomenon in all biological organisms, defined by the loss of
reproductive capacity and a progressive decline in fitness. In humans, aging is further …

Rationale: The circadian clock coordinates cell proliferation and metabolism and impacts the
progression of some diseases, particularly cancer. Pharmacological modulation of the …

Gastrointestinal (GI) cancers comprise a heterogeneous group of complex disorders that
affect different organs, including esophagus, stomach, gallbladder, liver, biliary tract …

Helicobacter Pylori is a gram negative rod shaped microaerophilic bacterium that colonizes
the stomach of approximately half the world's population. Infection with c may cause chronic …