Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed
a central role in the development and differentiation of steroidogenic tissues. SF-1 controls …

The adrenal gland is an essential stress-responsive organ that is part of both the
hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullary system. Chronic …

Lineage conversion of differentiated cells in response to hormonal feedback has yet to be
described. To investigate this, we studied the adrenal cortex, which is composed of …

Summary Background Steroidogenic factor 1 (SF-1/NR5A1) is essential for human sex
development. Heterozygous NR5A1/SF-1 variants manifest with a broad range of …

The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

Abstract Steroidogenic factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription
factor, has a pivotal role in adrenal and gonadal development in humans and mice. A …

The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1) is essential for adrenal
development and regulates genes that specify differentiated adrenocortical function. The …

A number of organs have the intrinsic ability to regenerate, a distinctive feature that varies
among organisms. Organ regeneration is a process not fully yet understood. However, when …

Steroidogenic factor 1 (SF-1, also called Ad4BP and NR5A1) is a nuclear receptor with
critical roles in steroidogenic tissues, as well as in the brain and pituitary. In particular, SF-1 …