Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition
could be caused by defects of the hepatocytes, which are responsible for the complex …

Cholestasis is the predominate feature of many pediatric hepatobiliary diseases. The
physiologic flow of bile requires multiple complex processes working in concert. Bile acid …

The safety of microplastics (MPs) and associated health effects has been one of the major
concerns worldwide. However, the role of photoaging toward the risk of MPs in water …

X-linked myotubular myopathy (XLMTM) is a fatal congenital disorder caused by mutations
in the MTM1 gene. Currently, there are no approved treatments, although AAV8-mediated …

Bile is a yellow‐green liquid produced in the liver from cholesterol and stored in the
gallbladder of vertebrates. Bile improves the efficacy of lipid digestion by acting as an …

The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …

The use of zebrafish larvae in basic and applied research has grown exponentially during
the last 20 years. The reasons for this success lay in its specific experimental advantages …

Bile salt synthesis, secretion into the intestinal lumen, and resorption in the ileum occur in all
vertebrate classes. In mammals, bile salt composition is determined by host and microbial …

In fish, the intestine is fundamental for digestion, nutrient absorption, and other functions like
osmoregulation, acid-base balance, and excretion of some metabolic products. These …

BACKGROUND Progressive familial intrahepatic cholestasis (PFIC) refers to a disparate
group of autosomal recessive disorders that are linked by the inability to appropriately form …