DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …

The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …

Glioblastomas exhibit widespread molecular alterations including a highly distorted
epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine …

Advances in genomic technology have enabled the faithful detection and measurement of
mutations and the gene expression profile of cancer cells at the single-cell level. Recently …

Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, extracellular …

Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose
patients to aggressive tumors characterized by pseudohypoxic and hypermethylator …

DNA methylation at the 5-position of cytosine (5mC) is an epigenetic modification that
regulates gene expression and cellular plasticity in development and disease. The ten …

DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic
modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC) …