Aggression and violence represent a significant public health concern and a clinical
challenge for the mental healthcare provider. A great deal has been revealed regarding the …

Objective: Involvement of personality traits in susceptibility to suicidality has been the subject
of research since the 1950s. Because of the diversity of conceptual and methodological …

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disorders with a complex inheritance pattern. While many rare variants in synaptic proteins …

Context High neuroticism is a personality risk factor that reflects much of the genetic
vulnerability to major depressive disorder (MDD), and low extraversion may increase risk as …

Context The importance of neuroticism for mental health care use and public health is well
established. However, most research has focused on the association between neuroticism …

Molecular genetic studies of personality began with two high impact papers in 1996 that
showed provisional associations between the dopamine DRD4 exon III repeat region and …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

The serotonin system is strongly implicated in the pathophysiology and therapeutic
alleviation of stress-related disorders such as anxiety and depression. Serotonergic …

Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to
dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the …

The highly diverse serotonergic system with at least 16 different receptor subtypes is
implicated in the pathophysiology of most neuropsychiatric disorders including affective and …