Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in
women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for …

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes
ranging from embryogenesis to wound healing and has strong links to several hallmarks of …

The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take
up more glucose than normal tissue and favor incomplete oxidation of glucose even in the …

A novel series of N-aryl-N′-pyrimidin-4-yl ureas has been optimized to afford potent and
selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by …

A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole
core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast …

Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their
continued proliferation and survival. Myc and HIF-1 are believed to promote such a …

Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Cancer is a complex genetic disease that develops from the accumulation of genomic
alterations in which germline variations predispose individuals to cancer and somatic …

The Warburg effect describes an increase in aerobic glycolysis and enhanced lactate
production in cancer cells. Lactate dehydrogenase A (LDH-A) regulates the last step of …