Sodium–Glucose cotransporter 2 inhibitor empagliflozin decreases ventricular arrhythmia susceptibility by alleviating electrophysiological remodeling post-myocardial …

G Xue, X Yang, G Zhan, X Wang, J Gao… - Frontiers in …, 2022 - frontiersin.org
Background: Recent clinical trials indicate that sodium–glucose cotransporter 2 (SGLT2)
inhibitors improve cardiovascular outcomes in myocardial infarction (MI) patients, but the …

[HTML][HTML] β-adrenergic regulation of Ca2+ signaling in heart cells

B Yang, SQ Wang, HQ Yang - Biophysics Reports, 2024 - pmc.ncbi.nlm.nih.gov
β-adrenergic receptors (βARs) play significant roles in regulating Ca2+ signaling in cardiac
myocytes, thus holding a key function in modulating heart performance. βARs regulate the …

[HTML][HTML] Amlexanox Exhibits Cardioprotective Effects in 5/6 Nephrectomized Rats

RMSM Mohamed, SM Elshazly… - Brazilian Journal of …, 2023 - SciELO Brasil
Cardiorenal syndrome is a life-threatening condition. The aim of the current study was to
determine the cardioprotective effects of amlexanox in 5/6 nephrectomized rats. Rats were …

β-adrenergic receptors in cardiac muscle: it takes two to tango

E Niggli - Cardiovascular research, 2020 - academic.oup.com
Cardiac output is appropriately adjusted by changes of heart rate and muscle force to cover
the varying metabolic needs of the body. Adjustments of inotropy are accomplished by fine …

Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes

P Saxena, RC Myles, GL Smith… - Pflügers Archiv-European …, 2022 - Springer
Atrial fibrillation (AF) from elevated adrenergic activity may involve increased atrial L-type
Ca2+ current (ICaL) by noradrenaline (NA). However, the contribution of the adrenoceptor …

Cardiomyocyte-Specific Deletion of β 2-Adrenergic Receptor Triggers Ca v1.2-Dependent Inflammation and Cardiac Dysfunction

C Zhu, M Zhao, Y Zhang, B Deng, SM Bahriz… - Available at SSRN … - papers.ssrn.com
Objectives To examine the pathophysiological role of 2 adrenergic receptors in the heart in
vivo. Backgroundβ-adrenergic signaling (βAR) is a major regulator of cardiac excitation and …