Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In
HL, the tumor cells—Hodgkin and Reed-Sternberg (HRS) cells—are usually very rare in the …

To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are developing lentiviral short hairpin …

Cellular phenotypes are determined by the differential activity of networks linking
coregulated genes. Available methods for the reverse engineering of such networks from …

Using current diagnostic criteria, primary mediastinal B cell lymphoma (PMBL) cannot be
distinguished from other types of diffuse large B cell lymphoma (DLBCL) reliably. We used …

Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large
B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young …

Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …

Mammalian genomes contain many repetitive elements, including long terminal repeats
(LTRs), which have long been suspected to have a role in tumorigenesis. Here we present …

The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its
relationship to other lymphomas are largely unknown. This is partly because of the technical …

Organisms have evolved sophisticated and redundant mechanisms to manage oxidative
and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for …