The future of rodent models in depression research

A Gururajan, A Reif, JF Cryan, DA Slattery - Nature Reviews …, 2019 - nature.com
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Ethological approach to social isolation effects in behavioral studies of laboratory rodents

H Arakawa - Behavioural brain research, 2018 - Elsevier
The aim of the present review is to discuss how housing conditions affect behavioral
performance in laboratory rodents from an ethological view. Commonly used laboratory …

[HTML][HTML] Molecular and neurocircuitry mechanisms of social avoidance

AK Gellner, J Voelter, U Schmidt, EC Beins… - Cellular and Molecular …, 2021 - Springer
Humans and animals live in social relationships shaped by actions of approach and
avoidance. Both are crucial for normal physical and mental development, survival, and well …

[HTML][HTML] The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

A Koert, A Ploeger, CLH Bockting, MV Schmidt… - Neurobiology of …, 2021 - Elsevier
Background Social stress is an important environmental risk factor for the development of
psychiatric disorders, including depression and anxiety disorders. Social stress paradigms …

[HTML][HTML] Psychological stress, its reduction, and long-term consequences: What studies with laboratory animals might teach us about life in the dog shelter

MB Hennessy, RM Willen, PA Schiml - Animals, 2020 - mdpi.com
Simple Summary Experiments in laboratory animals have provided the basis for studies of
stress, its reduction, and its long-term consequences in shelter dogs. Stressors often used in …

[HTML][HTML] Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models

M Horiai, A Otsuka, S Hidema, Y Hiraoka, R Hayashi… - Scientific reports, 2020 - nature.com
Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs
new therapeutic approaches. Recently, oxytocin (OXT) showed potential as the first anti …

Social status in mouse social hierarchies is associated with variation in oxytocin and vasopressin 1a receptor densities

W Lee, LC Hiura, E Yang, KA Broekman, AG Ophir… - Hormones and …, 2019 - Elsevier
The neuropeptides oxytocin and vasopressin and their receptors have established roles in
the regulation of mammalian social behavior including parental care, sex, affiliation and pair …

[HTML][HTML] Long-term impacts of post-weaning social isolation on nucleus accumbens function

CJ Bendersky, AA Milian, MD Andrus… - Frontiers in …, 2021 - frontiersin.org
Adolescence is a period of incredible change, especially within the brain's reward circuitry.
Stress, including social isolation, during this time has profound effects on behaviors …

Social network stability is impacted by removing a dominant male in replicate dominance hierarchies of a cichlid fish

TJ Piefke, TR Bonnell, GM DeOliveira, SE Border… - Animal Behaviour, 2021 - Elsevier
Highlights•Cichlid fish form dominance hierarchies in which males fight for territories.•In
groups of cichlid fish, we vacated a territory by removing a territorial male.•This created …

Long-lasting effects of postweaning sleep deprivation on cognitive function and social behaviors in adult mice

B Huang, B Sun, R Yang, S Liang, X Li, Y Guo… - …, 2022 - Elsevier
Sleep deprivation (SD) has adverse effects on physical and mental health. Recently
increasing attention has been given to SD in the early-life stage. However, the effects and …