[HTML][HTML] Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces

N Lee, S Hwang, J Kim, S Cho, B Palsson… - Computational and …, 2020 - Elsevier
Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

[HTML][HTML] Recent Advances in Silent Gene Cluster Activation in Streptomyces

Z Liu, Y Zhao, C Huang, Y Luo - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Natural products (NPs) are critical sources of drug molecules for decades. About two-thirds
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …

SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes

E Martínez-García, S Fraile, E Algar… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The SEVA platform (https://seva-plasmids. com) was launched one decade ago,
both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis …

[HTML][HTML] Thirty complete Streptomyces genome sequences for mining novel secondary metabolite biosynthetic gene clusters

N Lee, W Kim, S Hwang, Y Lee, S Cho, B Palsson… - Scientific data, 2020 - nature.com
Streptomyces are Gram-positive bacteria of significant industrial importance due to their
ability to produce a wide range of antibiotics and bioactive secondary metabolites. Recent …

Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition

C Zhan, N Lee, G Lan, Q Dan, A Cowan, Z Wang… - Nature …, 2023 - nature.com
Corynebacterium glutamicum is a promising host for production of valuable polyketides.
Propionate addition, a strategy known to increase polyketide production by increasing …

Natural product discovery through microbial genome mining

E Kenshole, M Herisse, M Michael, SJ Pidot - Current Opinion in Chemical …, 2021 - Elsevier
The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes

N Lee, S Hwang, W Kim, Y Lee, JH Kim, S Cho… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …

[HTML][HTML] Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs

HL Robertsen, EM Musiol-Kroll - Antibiotics, 2019 - mdpi.com
Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …

Synthetic biology-inspired strategies and tools for engineering of microbial natural product biosynthetic pathways

K Alam, J Hao, Y Zhang, A Li - Biotechnology Advances, 2021 - Elsevier
Microbial-derived natural products (NPs) and their derivative products are of great
importance and used widely in many fields, especially in pharmaceutical industries …

[HTML][HTML] Complete genome sequencing and in silico genome mining reveal the promising metabolic potential in Streptomyces strain CS-7

K Alam, J Hao, L Zhong, G Fan, Q Ouyang… - Frontiers in …, 2022 - frontiersin.org
Gram-positive Streptomyces bacteria can produce valuable secondary metabolites.
Streptomyces genomes include huge unknown silent natural product (NP) biosynthetic gene …