[HTML][HTML] Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces
Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …
metabolites, many of which have important clinical applications. With the advances in high …
[HTML][HTML] Recent Advances in Silent Gene Cluster Activation in Streptomyces
Z Liu, Y Zhao, C Huang, Y Luo - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Natural products (NPs) are critical sources of drug molecules for decades. About two-thirds
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …
SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes
E Martínez-García, S Fraile, E Algar… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The SEVA platform (https://seva-plasmids. com) was launched one decade ago,
both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis …
both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis …
[HTML][HTML] Thirty complete Streptomyces genome sequences for mining novel secondary metabolite biosynthetic gene clusters
Streptomyces are Gram-positive bacteria of significant industrial importance due to their
ability to produce a wide range of antibiotics and bioactive secondary metabolites. Recent …
ability to produce a wide range of antibiotics and bioactive secondary metabolites. Recent …
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition
Corynebacterium glutamicum is a promising host for production of valuable polyketides.
Propionate addition, a strategy known to increase polyketide production by increasing …
Propionate addition, a strategy known to increase polyketide production by increasing …
Natural product discovery through microbial genome mining
The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …
new natural products. Also known as specialized metabolites, these compounds produced …
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
[HTML][HTML] Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs
HL Robertsen, EM Musiol-Kroll - Antibiotics, 2019 - mdpi.com
Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …
medicine as well as for agriculture. The genomes of those microorganisms possess several …
Synthetic biology-inspired strategies and tools for engineering of microbial natural product biosynthetic pathways
K Alam, J Hao, Y Zhang, A Li - Biotechnology Advances, 2021 - Elsevier
Microbial-derived natural products (NPs) and their derivative products are of great
importance and used widely in many fields, especially in pharmaceutical industries …
importance and used widely in many fields, especially in pharmaceutical industries …
[HTML][HTML] Complete genome sequencing and in silico genome mining reveal the promising metabolic potential in Streptomyces strain CS-7
K Alam, J Hao, L Zhong, G Fan, Q Ouyang… - Frontiers in …, 2022 - frontiersin.org
Gram-positive Streptomyces bacteria can produce valuable secondary metabolites.
Streptomyces genomes include huge unknown silent natural product (NP) biosynthetic gene …
Streptomyces genomes include huge unknown silent natural product (NP) biosynthetic gene …