Synthetic gene expression in engineered cells typically depends on the host cell's limited
pool of intracellular resources, which can lead to resource competition between native and …

MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate
gene expression on post-transcriptional level via inhibition or degradation of specific …

Cells adopt a size that is optimal for their function, and pushing them beyond this limit can
cause cell aging and death by senescence or reduce proliferative potential. However, by …

Copy number variation through gene or chromosome amplification provides a route for rapid
phenotypic variation and supports the long-term evolution of gene functions. Although the …

Experimental observations tracing back to the 1960s imply that ribosome quantities play a
prominent role in determining a cell's growth. Nevertheless, in biologically relevant …

The processes of gene expression are inherently stochastic, even for essential genes
required for growth. How does the cell maximize fitness in light of noise? To answer this …

The identification of FACT as a histone chaperone enabling transcription through chromatin
in vitro has strongly shaped how its roles are envisioned. However, FACT has been …

Coordination of transcription and processing of RNA is a basic principle in regulation of
gene expression in eukaryotes. In the case of mRNA, coordination is primarily founded on a …

Many cells display considerable functional plasticity and depend on the regulation of
numerous organelles and macromolecules for their maintenance. In large cells, organelles …

Cell survival requires the control of biomolecule concentration, ie biomolecules should
approach homeostasis. With information-carrying macromolecules, the particular …