Immunometabolism in the pathogenesis of systemic lupus erythematosus: an update
J Romo-Tena, MJ Kaplan - Current opinion in rheumatology, 2020 - journals.lww.com
Fundamental new insights regarding the role of mitochondrial dysfunction in innate immune
dysregulation in SLE pathogenesis have recently emerged. Defects in specific molecular …
dysregulation in SLE pathogenesis have recently emerged. Defects in specific molecular …
Innate sensing and cellular metabolism: role in fine tuning antiviral immune responses
D Ahmed, M Al-Daraawi, E Cassol - Journal of Leukocyte …, 2023 - academic.oup.com
Several studies over the last decade have identified intimate links between cellular
metabolism and macrophage function. Metabolism has been shown to both drive and …
metabolism and macrophage function. Metabolism has been shown to both drive and …
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice
KA Fortner, LP Blanco, I Buskiewicz… - Lupus science & …, 2020 - lupus.bmj.com
Objectives Recent investigations in humans and mouse models with lupus have revealed
evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen …
evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen …
Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition
L Noël-Romas, M Perner, R Molatlhegi… - PLoS …, 2020 - journals.plos.org
Alterations to the mucosal environment of the female genital tract, such as genital
inflammation, have been associated with increased HIV acquisition in women. As the …
inflammation, have been associated with increased HIV acquisition in women. As the …
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies
Mitochondrial respiration is essential for the survival and function of T cells used in adoptive
cellular therapies. However, strategies that specifically enhance mitochondrial respiration to …
cellular therapies. However, strategies that specifically enhance mitochondrial respiration to …
Immunometabolic maladaptations to the tumor microenvironment
ES Hathaway, EQ Jennings… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
Tumors consist of cancer cells and a wide range of tissue resident and infiltrating cell types.
Tumor metabolism, however, has largely been studied on whole tumors or cancer cells and …
Tumor metabolism, however, has largely been studied on whole tumors or cancer cells and …
Effects of altered glycolysis levels on CD8+ T cell activation and function
J Cao, S Liao, F Zeng, Q Liao, G Luo, Y Zhou - Cell Death & Disease, 2023 - nature.com
CD8+ T cells are an important component of the body's adaptive immune response. During
viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated …
viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated …
Sinapine improves LPS-induced oxidative stress in hepatocytes by down-regulating MCJ protein expression
Y Li, YJ Xu, CP Tan, Y Liu - Life Sciences, 2022 - Elsevier
Oxidative stress is an important part of the development of NAFLD, and hepatic injury can be
prevented by inhibiting oxidative stress. In this study, we investigated the potential role of …
prevented by inhibiting oxidative stress. In this study, we investigated the potential role of …
Molecular and temporal control of restimulation-induced cell death (RICD) in T lymphocytes
For effective adaptive immunity, T lymphocytes must rapidly expand and contract in an
antigen-specific manner to effectively control invading pathogens and preserve …
antigen-specific manner to effectively control invading pathogens and preserve …
[HTML][HTML] Selective DNA demethylation accompanies T cell homeostatic proliferation and gene regulation in lupus-prone lpr mice
CD Scharer, KA Fortner, JA Dragon, S Tighe… - …, 2020 - journals.aai.org
Systemic lupus erythematosus (SLE) is characterized by increased DNA demethylation in T
cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The …
cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The …