Fundamental new insights regarding the role of mitochondrial dysfunction in innate immune
dysregulation in SLE pathogenesis have recently emerged. Defects in specific molecular …

Several studies over the last decade have identified intimate links between cellular
metabolism and macrophage function. Metabolism has been shown to both drive and …

Objectives Recent investigations in humans and mouse models with lupus have revealed
evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen …

Alterations to the mucosal environment of the female genital tract, such as genital
inflammation, have been associated with increased HIV acquisition in women. As the …

Mitochondrial respiration is essential for the survival and function of T cells used in adoptive
cellular therapies. However, strategies that specifically enhance mitochondrial respiration to …

Tumors consist of cancer cells and a wide range of tissue resident and infiltrating cell types.
Tumor metabolism, however, has largely been studied on whole tumors or cancer cells and …

CD8+ T cells are an important component of the body's adaptive immune response. During
viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated …

Oxidative stress is an important part of the development of NAFLD, and hepatic injury can be
prevented by inhibiting oxidative stress. In this study, we investigated the potential role of …

For effective adaptive immunity, T lymphocytes must rapidly expand and contract in an
antigen-specific manner to effectively control invading pathogens and preserve …

Systemic lupus erythematosus (SLE) is characterized by increased DNA demethylation in T
cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The …