Abstract The Interleukin (IL)-10 cytokine family includes IL-10, IL-19, IL-20, IL-22, IL-24, and
IL-26, which are considered as Class 2α-helical cytokines. IL-10 is the most important …

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type
I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this …

Abstract Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24) is a
pleiotropic member of the IL-10 family of cytokines, and is involved in multiple biological …

Neuroinflammation is critically involved in nerve injury-induced neuropathic pain,
characterized by local and systemic increased levels of proinflammatory cytokines …

Human interleukin 24 (IL-24) is a multifunctional cytokine that represents an important target
for autoimmune diseases and cancer. Since the biological functions of IL-24 depend on …

Targeted delivery of therapeutic anticancer chimeric molecules enhances the efficacy of
drug by improving cellular uptake and circulation time. Engineering the molecules to …

IL-20 is a pleiotropic cytokine that belongs to the IL-10 family and has a variety of biological
functions in tissue homeostasis and regulation of host immune defenses. It signals through a …

Interleukin 24 (IL‐24) is a cytokine with the potential to be an effective treatment for
autoimmune diseases and cancer. However, its instability and difficulties in its production …

We hereby describe the process of design and selection of nonantibody protein binders
mimicking cytokine signaling. We chose to mimic signaling of IFN‐λ1, type 3 interferon (also …

Background Human proteins such as interleukin-24 (IL24), thyroperoxidase (TPO) and
thyroglobulin (Tg) are targets of IgE or IgG autoantibodies. Why these proteins are …