[HTML][HTML] Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Leishmania mexicana Inhibitors
LD González-Morales, A Moreno-Rodríguez… - Pharmaceutics, 2023 - mdpi.com
Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries
worldwide. No vaccine is available to prevent the disease, and available medical treatments …
worldwide. No vaccine is available to prevent the disease, and available medical treatments …
[HTML][HTML] Ligand-based virtual screening and molecular docking of benzimidazoles as potential inhibitors of triosephosphate isomerase identified new trypanocidal …
LK Vázquez-Jiménez, A Juárez-Saldivar… - International Journal of …, 2022 - mdpi.com
Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. cruzi
depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and …
depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and …
Новое предназначение старых лекарств (обзор)
ИИ Мирошниченко, ЕА Вальдман… - Разработка и …, 2023 - pharmjournal.ru
Аннотация Введение. Для использования лекарственного препарата, который
применяют при лечении одного заболевания, на профилактику и лечение другого …
применяют при лечении одного заболевания, на профилактику и лечение другого …
[HTML][HTML] Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana
LK Vázquez-Jiménez, A Juárez-Saldivar… - Pharmaceuticals, 2023 - mdpi.com
Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a
“Neglected disease”, for which the search for new drugs is a priority. Benzimidazole is a …
“Neglected disease”, for which the search for new drugs is a priority. Benzimidazole is a …
Molecular docking and dynamic simulations of quinoxaline 1, 4-di-N-oxide as inhibitors for targets from Trypanosoma cruzi, Trichomonas vaginalis, and Fasciola …
A González-González, D Méndez-Álvarez… - Journal of Molecular …, 2023 - Springer
Abstract Context Quinoxaline 1, 4-di-N-oxide is a scaffold with a wide array of biological
activities, particularly its use to develop new antiparasitic agents. Recently, these …
activities, particularly its use to develop new antiparasitic agents. Recently, these …
Data mining and molecular dynamics analysis to detect HIV-1 reverse transcriptase RNase H activity inhibitor
HIV-1 is a deadly virus that affects millions of people worldwide. In this study, we aimed to
inhibit viral replication by targeting one of the HIV-1 proteins and identifying a new drug …
inhibit viral replication by targeting one of the HIV-1 proteins and identifying a new drug …
Design, synthesis and systemic acquired resistance of 2-benzothiadiazolylquinoline-4-carboxamides by COI1 based virtual screening
X Liu, H Yang, Y Sun, Y Huang, S Hong, H Yuan… - Molecular Diversity, 2024 - Springer
Abstract Coronatine-insensitive 1 (COI1) has been identified as a target receptor of plant
elicitor coronatine (COR). To discover novel plant elicitor leads, most of the potential …
elicitor coronatine (COR). To discover novel plant elicitor leads, most of the potential …
Old drugs, new indications
II Miroshnichenko, EA Valdman… - Drug development & …, 2023 - pharmjournal.ru
Introduction. The drug can be used in the treatment of one disease and for the prevention
and treatment of another pathological process. This is possible due to the repurposing of …
and treatment of another pathological process. This is possible due to the repurposing of …