Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …

Summary SARS-CoV-2 Lambda, a variant of interest, has spread in some South American
countries; however, its virological features and evolutionary traits remain unclear. In this …

Humanized mouse models that have received human cells or tissue transplants are
extremely useful in basic and applied human disease research. Highly immunodeficient …

Background Acquired hemophagocytic lymphohistiocytosis (HLH) is a life-threatening event
that usually occurs as a complication of immunodeficiency. Lung involvement in HLH has …

Hemophagocytic lymphohistiocytosis (HLH) comprises a group of life-threatening immune
disorders classified into primary or secondary HLH. The former is caused by mutations in …

Most pathogens are able to infect multiple hosts but some are highly adapted to a single-
host species. A detailed understanding of the basis of host specificity can provide important …

Cell-to-cell viral infection, in which viruses spread through contact of infected cell with
surrounding uninfected cells, has been considered as a critical mode of virus infection …

The development of animal models that mimic human allergic responses is crucial to study
the pathophysiology of disease and to generate new therapeutic methodologies …

With an increasing human population, medical research is pushed to progress into an era of
precision therapy. Humanized mice are at the very heart of this new forefront where it is …