Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …

Ninety percent of plasma fatty acids (FAs) are contained within lipoprotein-triglyceride, and
lipoprotein lipase (LPL) is robustly expressed in the heart. Hence, LPL-mediated lipolysis of …

Aims Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells
such as cardiomyocytes. Whereas many studies support the importance of autophagy in the …

Proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues.
Recent studies have identified GPIHBP1 as the molecule that transports LPL to the capillary …

Background Lipoprotein lipase (LPL)‐derived fatty acid is a major source of energy for
cardiac contraction. Synthesized in cardiomyocytes, LPL requires translocation to the …

Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen
species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can …

Although cardiovascular disease is the leading cause of diabetes-related death, its etiology
is still not understood. The immediate change that occurs in the diabetic heart is altered …

The heart responds to stresses such as chronic hypertension and myocardial infarction by
undergoing a remodeling process that is associated with myocyte hypertrophy, myocyte …

Objective—Lipoprotein lipase (LPL)–mediated triglyceride hydrolysis is the major source of
fatty acid for cardiac energy. LPL, synthesized in cardiomyocytes, is translocated across …

Obesity due to nutrient excess leads to chronic pathologies including type 2 diabetes and
cardiovascular disease. Related to nutrient excess, FoxO1 has a role in regulating fatty acid …