Transforming growth factor-beta (TGF-β) isoforms are cytokines involved in a variety of
cellular processes, including myofiber repair and regulation of connective tissue formation …

Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue
healing leading to loss of its architecture and function. Fibrotic diseases are often associated …

Skeletal muscle is a tissue that shows the most plasticity in the body; it can change in
response to physiological and pathological stimuli. Among the diseases that affect skeletal …

CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF),
is one of the founding members of the CCN family of matricellular proteins. Extensive …

The production of force and power are inherent properties of skeletal muscle, and regulated
by contractile proteins within muscle fibers. However, skeletal muscle integrity and function …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the
loss of strength and muscle mass. A feature of muscle atrophy is a decrease of myofibrillar …

Several skeletal muscle diseases are characterized by fibrosis, the excessive accumulation
of extracellular matrix. Transforming growth factor-β (TGF-β) and connective tissue growth …

Duchenne muscular dystrophy (DMD) is one of the most devastating neuromuscular genetic
diseases caused by the absence of dystrophin. The continuous episodes of muscle …

In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue
Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion …