Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the
last 20 years, much experience has been gained in measurement and interpretation of these …

Alkaline phosphatase (ALP) is an evolutionary conserved enzyme and widely used
biomarker in clinical practice. Tissue-nonspecific alkaline phosphatase (TNALP) is one of …

Background. A number of US observational studies reported an increased mortality risk with
higher intact parathyroid hormone (iPTH), calcium and/or phosphate. The existence of such …

This commentary provides a US perspective on the 2009 KDIGO (Kidney Disease:
Improving Global Outcomes) Clinical Practice Guideline for the Diagnosis, Evaluation …

Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be
found in many animal and plant species. Mystery surrounds the precise functional role of …

Circulating biochemical markers of bone remodeling in uremic patients. Chronic renal failure
is often associated with bone disorders, including secondary hyperparathyroidism …

Background Renal osteodystrophy is common in advanced CKD, but characterization of
bone turnover status can only be achieved by histomorphometric analysis of bone biopsy …

Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in
ESRD patients. Background The “intact” parathyroid hormone (PTH) assay recognizes PTH …

Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) comprises alterations in
calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 …

THE ABNORMALITIES of the skeleton in chronic kidney disease (CKD), collectively known
as renal osteodystrophy, are an important cause of morbidity and decreased quality of life. In …