Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

Leishmaniasis, including the cutaneous form, poses an important public health threat
around the world, while no vaccine is currently available against any form of leishmaniasis …

Leishmaniasis and Chagas disease, two of the most prevalent neglected tropical diseases,
are a world health problem. The harsh reality of these infective diseases is the absence of …

In this study, we synthesized (2-propoxyphenyl)(3-(p-tolyl) oxiran-2-yl) methanone through
oxidizing the double bond of the respective chalcone via the Weitz–Scheffer epoxidation …

Current therapies of leishmaniasis and Chagas disease, two of the most widespread
neglected tropical diseases, have limited efficacy and toxic side effects. In this regard …

Withania somnifera (L.) Dunal, abundant in the Indian subcontinent as Ashwagandha or
winter cherry, is a herb of unprecedented therapeutic value. The number of ailments for …

Eleven highly oxidized withanolides, chantriolides F–P (1–11), together with six known
analogues (12–17), were isolated from the rhizomes of Tacca chantrieri. Their structures …

Abstract Ethnopharmacological relevance The genus Physalis L.(Solanaceae) is commonly
used in the treatment of dermatitis, leprosy, bronchitis, pneumonia, hepatitis and rheumatism …

The current study aims to understand the binding mechanism and intermolecular
interactions of the novel Withangulatin A derivatives towards the allosteric site of …

Abstract Treatment against leishmaniasis presents problems, mainly due to the toxicity of the
drugs, high cost, and the emergence of resistant strains. A previous study showed that two …