Hallmarks of cancer: new dimensions
D Hanahan - Cancer discovery, 2022 - AACR
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …
Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
Genetic mechanisms of immune evasion in colorectal cancer
To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
Although approved programmed cell death protein (PD)-1 inhibitors show durable
responses, clinical benefits to these agents are only seen in one-third of patients in most …
responses, clinical benefits to these agents are only seen in one-third of patients in most …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
The role of enhancers in cancer
Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …
most important functions is the integration of extracellular signals with intracellular cell fate …
Overview on clinical relevance of intra-tumor heterogeneity
G Stanta, S Bonin - Frontiers in medicine, 2018 - frontiersin.org
Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …