Rotors and the dynamics of cardiac fibrillation

SV Pandit, J Jalife - Circulation research, 2013 - Am Heart Assoc
The objective of this article is to present a broad review of the role of cardiac electric rotors
and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset …

Ventricular arrhythmias and the His–Purkinje system

M Haissaguerre, E Vigmond, B Stuyvers… - Nature Reviews …, 2016 - nature.com
Ventricular arrhythmias are a major cause of sudden death, which accounts for
approximately half of cardiac mortality. The His–Purkinje system is composed of specialized …

Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care

AR Panchal, JA Bartos, JG Cabañas, MW Donnino… - Circulation, 2020 - Am Heart Assoc
These guidelines contain recommendations for basic life support (BLS) and advanced life
support (ALS) for adult patients and are based on the best available resuscitation science …

Early afterdepolarizations and cardiac arrhythmias

JN Weiss, A Garfinkel, HS Karagueuzian, PS Chen… - Heart rhythm, 2010 - Elsevier
Early afterdepolarizations (EADs) are an important cause of lethal ventricular arrhythmias in
long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular …

So little source, so much sink: requirements for afterdepolarizations to propagate in tissue

Y Xie, D Sato, A Garfinkel, Z Qu, JN Weiss - Biophysical journal, 2010 - cell.com
How early (EADs) and delayed afterdepolarizations (DADs) overcome electrotonic source-
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …

Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function

G Schram, M Pourrier, P Melnyk, S Nattel - Circulation research, 2002 - Am Heart Assoc
The cardiac electrical system is designed to ensure the appropriate rate and timing of
contraction in all regions of the heart, which are essential for effective cardiac function. Well …

Nonlinear and stochastic dynamics in the heart

Z Qu, G Hu, A Garfinkel, JN Weiss - Physics reports, 2014 - Elsevier
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Ventricular fibrillation: mechanisms of initiation and maintenance

J Jalife - Annual review of physiology, 2000 - annualreviews.org
▪ Abstract Ventricular fibrillation (VF) is the major immediate cause of sudden cardiac death.
Traditionally, VF has been defined as turbulent cardiac electrical activity, which implies a …

Brugada syndrome

C Antzelevitch - Pacing and clinical electrophysiology, 2006 - Wiley Online Library
First introduced as a new clinical entity in 1992, the Brugada syndrome is associated with a
relatively high risk of sudden death in young adults, and occasionally in children and infants …

Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias

D Sato, LH Xie, AA Sovari, DX Tran… - Proceedings of the …, 2009 - National Acad Sciences
The synchronization of coupled oscillators plays an important role in many biological
systems, including the heart. In heart diseases, cardiac myocytes can exhibit abnormal …