Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and
public health strategies. Viral–host interactions can guide discovery of disease regulators …

Dengue is a major worldwide problem in tropical and subtropical areas; it is caused by four
different viral serotypes, and it can manifest as asymptomatic, mild, or severe. Many factors …

Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

Purpose To identify genetic variants associated with complement activation, which may help
to select age-related macular degeneration (AMD) patients for complement-inhibiting …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …

Acute and chronic kidney failure is common in hospitalized patients with COVID-19, yet the
mechanism of injury and predisposing factors remain poorly understood. We investigated …

One of the main challenges in the clinical management of dengue is the early identification
of cases that could progress to severe forms of the disease. A biomarker that may enable …

Dengue is a mosquito-borne disease caused by infection with dengue virus (DENV) that
represents a serious and expanding global health threat. Most DENV infections are …

Dengue disease is an inflammatory‐driven pathology, and complement overactivation is
linked to disease severity and vascular leakage. Additionally, dysregulation of complement …

Abstract Background Dengue and West Nile viruses are highly cross-reactive and have
numerous parallels in geography, potential vector host (Aedes family of mosquitoes), and …