It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

Oxygen free radicals, any chemical moiety containing an oxygen atom with an unpaired
electron in the outer orbital shell, are generated during many normal biochemical reactions …

The aetiology and pathogenesis of Alzheimer's disease are currently poorly understood, but
symptomatic disease is associated with amyloid plaques, neurofibrillary tangles, neuronal …

In spite of the extensive studies performed on postmortem substantia nigra from Parkinson's
disease patients, the aetiology of the disease has not yet been established. Nevertheless …

The monoamine oxidase-B (MAO-B) inhibitor l-deprenyl (Selegiline) is effective in treating
Parkinson's disease and possibly Alzheimer's disease, with a concomitant extension of life …

The era of MAO-B inhibitors dates back more than 50 years. It began with Kálmán Magyar's
outstanding discovery of the selective inhibitor, selegiline. This compound is still regarded …

Daily sc injection of (−) deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused
a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain …

A series of aliphaticpropargylamine derivatives has been synthesized. Some of them
possess highly potent, irreversible, selective, inhibitory activity toward monoamineoxidase B …

Aging is associated with a progressive decline in physical and cognitive functions. The
impact of age-dependent endocrine changes regulated by the central nervous system on the …

Bacopa monniera is a perennial herb, and is used as a nerve tonic in äyurveda, a traditional
medicinal system in India. Aluminium-induced neurotoxicity is well known and different salts …