The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

Spinal muscular atrophy (SMA) is a hereditary neurodegenerative disease with severity
ranging from progressive infantile paralysis and premature death (type I) to limited motor …

Mutations in the family of neurexins (NRXN1, NRXN2 and NRXN3) have been repeatedly
identified in patients with autism spectrum disorder (ASD) and schizophrenia (SCZ) …

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and fronto-temporal
dementia (FTD) is a hexanucleotide repeat expansion within the C9orf72 gene. Reduced …

Importance Genome-wide association studies (GWASs) in European populations have
identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique …

Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal
muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor …

None of the current superresolution microscopy techniques can reliably image the changes
in endogenous protein nanoclustering dynamics associated with specific conformations in …

The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role
for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by …

Animal models have been an invaluable means to advance biomedical research as they
provide experimental avenues for cellular and molecular investigations of disease …

Formation of organ-specific vasculatures requires cross-talk between developing tissue and
specialized endothelial cells. Here we show how developing zebrafish spinal cord neurons …