Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Defensins: a double-edged sword in host immunity

D Xu, W Lu - Frontiers in immunology, 2020 - frontiersin.org
Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

Toll‐like receptor polymorphism in host immune response to infectious diseases: A review

S Mukherjee, S Huda… - Scandinavian journal of …, 2019 - Wiley Online Library
Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

Role of defensins in tumor biology

L Adyns, P Proost, S Struyf - International journal of molecular sciences, 2023 - mdpi.com
Defensins have long been considered as merely antimicrobial peptides. Throughout the
years, more immune-related functions have been discovered for both the α-defensin and β …

[HTML][HTML] Antimicrobial peptides with antiviral and anticancer properties and their modification and nanodelivery systems

M Yang, S Liu, C Zhang - Current Research in Biotechnology, 2023 - Elsevier
Antimicrobial peptides (AMPs) are natural biopolymers in the host defense system. AMPs
display multiple functions against bacterial, fungal, and viral infection, as well as anticancer …

Human beta defensins and cancer: contradictions and common ground

SK Ghosh, TS McCormick, A Weinberg - Frontiers in Oncology, 2019 - frontiersin.org
Human beta-defensins (hBDs,− 1, 2, 3) are a family of epithelial cell derived antimicrobial
peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to …

Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo

DM Metwally, EM Al-Olayan, M Alanazi… - … and alternative medicine, 2018 - Springer
Background Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by
trematode worms. The host inflammatory response to schistosome eggs leads to perioval …

Functions of antimicrobial peptides in vertebrates

E Edilia Avila - Current Protein and Peptide Science, 2017 - ingentaconnect.com
Objective: The aim of this review is to examine the multiple activities of antimicrobial
peptides (AMPs) in vertebrates. Content: The largest AMP families are the cathelicidins and …

Antitumor effect of copper nanoparticles on human breast and colon malignancies

M Al-Zharani, AA Qurtam, WM Daoush, MH Eisa… - … Science and Pollution …, 2021 - Springer
Breast and colon carcinomas are two types of common cancers which lead to cancer-related
deaths. Due to their cytotoxic potential against cancer cells, recently many studies of copper …

Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines

N Abutaha, FA Nasr, AZ Mohammed, AH Semlali… - Molecular biology …, 2019 - Springer
Calendula arvensis L. is used in traditional folk medicine for the treatment of several
diseases. Leaves, stems, and flowers of C. arvensis were extracted using a Soxhlet extractor …