Human papillomavirus (HPV)-induced cancers are expected to remain a major health
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell
carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic …

An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder
cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely …

Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

Links between human papillomaviruses (HPVs) and cervical cancer were first suspected
almost 30 years ago. DNA of specific HPV types has since been found in almost all cervical …

The E6 protein encoded by the oncogenic human papillomavirus types 16 and 16 is one of
two viral products expressed in HPV-associated cancers. E6 is an oncoprotein which …

The ubiquitin-dependent proteolytic pathway plays a major role in selective protein
degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …