Experimental diabetes induced by alloxan and streptozotocin: The current state of the art
M Radenković, M Stojanović, M Prostran - Journal of pharmacological and …, 2016 - Elsevier
Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal
models of diabetes represent an important tool in diabetes investigation that helps us to …
models of diabetes represent an important tool in diabetes investigation that helps us to …
The mechanisms of alloxan-and streptozotocin-induced diabetes
S Lenzen - Diabetologia, 2008 - Springer
Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in
pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular …
pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular …
Glucose transporters in pancreatic islets
C Berger, D Zdzieblo - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters
with distinct transport characteristics. In the pancreatic islet, facilitative diffusion glucose …
with distinct transport characteristics. In the pancreatic islet, facilitative diffusion glucose …
Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …
Streptozotocin-induced diabetes in large animals (pigs/primates): role of GLUT2 transporter and β-cell plasticity
D Dufrane, M van Steenberghe, Y Guiot… - …, 2006 - journals.lww.com
Background. To induce irreversible diabetes in large animals, the efficiency of streptozotocin
(STZ) was evaluated in pigs, primates and compared to the gold standard model in rats …
(STZ) was evaluated in pigs, primates and compared to the gold standard model in rats …
Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo
SM Phadnis, MV Joglekar, MP Dalvi, S Muthyala… - …, 2011 - Taylor & Francis
Background aims. The scarcity of human islets for transplantation remains a major limitation
of cell replacement therapy for diabetes. Bone marrow-derived progenitor cells are of …
of cell replacement therapy for diabetes. Bone marrow-derived progenitor cells are of …
Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research
S Renner, B Dobenecker, A Blutke, S Zoels, R Wanke… - Theriogenology, 2016 - Elsevier
The prevalence of diabetes mellitus, which currently affects 387 million people worldwide, is
permanently rising in both adults and adolescents. Despite numerous treatment options …
permanently rising in both adults and adolescents. Despite numerous treatment options …
Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells
The diabetogenic agent alloxan is selectively accumulated in insulin-producing cells
through uptake via the GLUT2 glucose transporter in the plasma membrane. In the presence …
through uptake via the GLUT2 glucose transporter in the plasma membrane. In the presence …
Chronic ethanol consumption-induced pancreatic β-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation
Chronic ethanol consumption is known as an independent risk factor for type 2 diabetes,
which is characterized by impaired glucose homeostasis and insulin resistance; however …
which is characterized by impaired glucose homeostasis and insulin resistance; however …
The role of peroxisome proliferator‐activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus
The pathogenesis of type 2 diabetes mellitus involves both peripheral insulin resistance and
dysfunctional insulin secretion from the pancreatic β cell. Currently, there is intense research …
dysfunctional insulin secretion from the pancreatic β cell. Currently, there is intense research …