The World Health Organization (WHO) has recognized obesity as one of the top ten threats
to human health. It is estimated that the number of obese and overweight people worldwide …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. As
mitochondrial dysfunction critically contributes to the pathogenesis of MI, intensive research …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Clear cell renal cell carcinoma (ccRCC) preferentially invades into perinephric adipose
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …

Chronic low-grade inflammation is a hallmark of obesity and its related metabolic disorders.
At the same time signaling from pro-inflammatory factors such as transforming growth factor …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be
responsible for the metabolic effects of coffee and tea consumption. Along with their …

The pathogenesis of Alzheimer's disease (AD), the most prevalent form of dementia,
remains unclear. Over the past few years, evidence has accumulated indicating that …