The functional and structural relationship among the individual components of the
mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic …

Recent studies have established that cellular electrostatic interactions are more influential
than assumed previously. Here, we use cryo-EM and perform steady-state kinetic studies to …

Mitochondrial membranes harbor the electron transport chain (ETC) that powers oxidative
phosphorylation (OXPHOS) and drives the synthesis of ATP. Yet, under physiological …

Respiratory complexes have co-evolved into supercomplexes in different clades to sustain
energy production at the basis of eukaryotic life. In parasites, they likely exhibit functional …

The biological significance of protein supercomplexes have remained contentious,
particularly how they tune the shuttling of charge-carrier redox proteins across cell …

Lipid bilayers are critical platforms for cellular homeostasis. The main components of lipid
bilayers are phospholipids, which contain various combinations of headgroup, and acyl …

The detailed catalytic activity of cytochrome bc1 (or respiratory complex III) and the
molecular mechanism of the Q cycle remain elusive. At the Qo site, the cycle begins with …

Mitochondria are compartmentalized by two membranes: the inner and outer membranes.
The inner mitochondrial membrane contains a series of multi-subunit complexes–respiratory …

The prevalence of antibiotic resistance continues to rise, rendering many valuable drugs
ineffective. Antibiotic cycling regimens that incorporate collateral sensitivity (CS), the …

The outer membrane of Gram-negative bacteria is a barrier to chemical and physical stress.
Phospholipid transport between the inner and outer membranes has been an area of …