Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Parkinson's disease (PD) is a neurodegenerative disorder caused by insufficient dopamine
production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine …

Glia continuously survey neuronal health during development, providing trophic support to
healthy neurons while rapidly engulfing dying ones. These diametrically opposed functions …

Pathological hallmarks of Alzheimer9s disease (AD) include amyloid-β (Aβ) plaques,
neurofibrillary tangles, and reactive gliosis. Glial cells offer protection against AD by …

Phagoptosis is a frequently occurring nonautonomous cell death pathway in which
phagocytes eliminate viable cells. While it is thought that phosphatidylserine (PS)“eat-me” …

Abstract Morphogenesis of the Central Nervous System (CNS) is a complex process that
obeys precise architectural rules. Yet, the mechanisms dictating these rules remain …

Glial phagocytosis is critical for the development and maintenance of the CNS in vertebrates
and flies and relies on the function of phagocytic receptors to remove apoptotic cells and …

Critical periods are temporally-restricted, early-life windows when sensory experience
remodels synaptic connectivity to optimize environmental input. In the Drosophila juvenile …

There are certain critical periods during pregnancy when the fetus is at high risk for
exposure to teratogens. Some microorganisms, including Toxoplasma gondii, are known to …

The clearance of dead and dying cells, termed efferocytosis, is a rapid and efficient process
and one that is critical for organismal health. The extraordinary speed and efficiency with …