Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Multicomponent reactions are flexible reactions for the rapid generation of complex
molecules with often biologically relevant scaffold structures. Combined with the ease of …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Sulfhydryl chemistry plays a vital role in normal biology and in defense of cells against
oxidants, free radicals, and electrophiles. Modification of critical cysteine residues is an …

Obesity is a major epidemic that poses a worldwide threat to human health, as it is also
associated with metabolic syndrome, type 2 diabetes and cardiovascular disease …

Abstract Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …

Obesity is a complex metabolic condition that can have a negative impact on one's health
and even result in mortality. The management of obesity has been addressed in a number of …

Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the
negative regulation of insulin signal transduction pathway and has emerged as novel …