The African turquoise killifish has recently gained significant traction as a new research
organism in the aging field. Our understanding of aging has strongly benefited from …

In the search for interventions against aging and age-related diseases, biological screening
platforms are indispensable tools to identify anti-aging compounds among large substance …

De novo point mutations in GNAO1, gene encoding the major neuronal G protein Gαo, have
recently emerged in patients with pediatric encephalopathy having motor, developmental …

Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact
of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies …

Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they
modulate physiology are unknown. We find that hunger modulates aging in Drosophila …

Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary
protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect …

Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …