Role of urotensin II in health and disease

B Ross, K McKendy, A Giaid - American Journal of …, 2010 - journals.physiology.org
Urotensin II (UII) is an 11 amino acid cyclic peptide originally isolated from the goby fish. The
amino acid sequence of UII is exceptionally conserved across most vertebrate taxa, sharing …

Endozepines and their receptors: structure, functions and pathophysiological significance

MC Tonon, H Vaudry, J Chuquet, F Guillebaud… - Pharmacology & …, 2020 - Elsevier
The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …

International union of basic and clinical pharmacology. XCII. Urotensin II, urotensin II–related peptide, and their receptor: From structure to function

H Vaudry, J Leprince, D Chatenet, A Fournier… - Pharmacological …, 2015 - ASPET
Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

EA Bearce, ZH Irons, JR O'Hara-Smith, CJ Kuhns… - Elife, 2022 - elifesciences.org
The spine provides structure and support to the body, yet how it develops its characteristic
morphology as the organism grows is little understood. This is underscored by the …

Urotensin II, from fish to human

H Vaudry, JC Do Rego, JC Le Mevel… - Annals of the New …, 2010 - Wiley Online Library
The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish
on the basis of its ability to contract intestinal smooth muscle. The UII peptide has …

From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function

SA Douglas, D Dhanak, DG Johns - Trends in pharmacological sciences, 2004 - cell.com
The identification of a human homolog of urotensin-II (U-II) and a novel, specific G-protein-
coupled receptor by Ames et al. in 1999 changed the perception that the U-II isopeptide …

Structure–activity relationships and structural conformation of a novel urotensin II-related peptide

D Chatenet, C Dubessy, J Leprince, C Boularan… - Peptides, 2004 - Elsevier
Urotensin II (UII) has been described as the most potent vasoconstrictor peptide and
recognized as the endogenous ligand of the orphan G protein-coupled receptor GPR14 …

Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families

H Tostivint, L Joly, I Lihrmann… - Proceedings of the …, 2006 - National Acad Sciences
Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their
precursors do not show any appreciable sequence identity and, thus, it is widely accepted …

Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord

F Bruzzone, B Lectez, H Tollemer… - Journal of …, 2006 - Wiley Online Library
Abstract 26RFa is a novel RFamide peptide originally isolated in the amphibian brain. The
26RFa precursor has been subsequently characterized in various mammalian species but …

Localization of the urotensin II receptor in the rat central nervous system

S Jégou, D Cartier, C Dubessy… - Journal of …, 2006 - Wiley Online Library
The vasoactive peptide urotensin II (UII) is primarily expressed in motoneurons of the
brainstem and spinal cord. Intracerebroventricular injection of UII provokes various …