Imidazoline receptors historically referred to a family of nonadrenergic binding sites that
recognize compounds with an imidazoline moiety, although this has proven to be an …

Since first introduced more than two decades ago, the research in imidazoline I 2 receptors
has been steadily increasing. This review provides an update on the current status of I 2 …

Astroglia are multifunctional cells that regulate neuroinflammation and maintain
homeostasis within the brain. Astroglial α-synuclein-positive cytoplasmic accumulations …

Understanding how neuronal circuits control nociceptive processing will advance the search
for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic …

The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any
acute or chronic, central or peripheral neurological disorder is related to abnormal …

Abstract Introduction. The alpha-2 adrenergic (AA-2) receptor agonists and imidazolines are
common exposures in the American Association of Poison Control Centers (AAPCC) …

Recent findings unveil the pharmacological modulation of imidazoline I 2 receptors (I 2-IR)
as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we …

Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that
suffer from neurodegenerative disorders, are orphans from a structural point of view, and …

Alpha-2 agonists have desirable effects, including sedation, analgesia, and minimum
alveolar concentration (MAC) sparing for inhalational anesthetics, and despite profound …

Background and Purpose A new imidazoline I 2 receptor ligand, CR 4056, is effective for
chronic inflammatory pain and diabetic neuropathy. However, it is unclear whether other I 2 …