In the last decade we have witnessed a dramatic increase in the proportion and absolute
number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant …

Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in
the 2000s as important human pathogens, have spread extensively throughout the world …

One of the major breakthroughs in the history of medicine is undoubtedly the discovery of
antibiotics. Their use in animal husbandry and veterinary medicine has resulted in healthier …

Abstract The Working Party makes more than 100 tabulated recommendations in
antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) …

In 2008, a previously unknown Escherichia coli clonal group, sequence type 131 (ST131),
was identified on three continents. Today, ST131 is the predominant E. coli lineage among …

Antimicrobial resistance (AMR) is now a global threat. Its emergence rests on antimicrobial
overuse in humans and food-producing animals; globalization and suboptimal infection …

Extra-intestinal pathogenic Escherichia coli (ExPEC) have a complex phylogeny, broad
virulence factor (VF) armament and significant genomic plasticity, and are associated with a …

Escherichia coli sequence type 131 (ST131) is an extensively antimicrobial-resistant E. coli
clonal group that has spread explosively throughout the world. Recent molecular …

Bloodstream infection (BSI) is a major cause of infectious disease morbidity and mortality
worldwide. While a positive blood culture is mandatory for establishment of the presence of …

Large-scale bacterial genome sequencing efforts to date have provided limited information
on the most prevalent category of disease: sporadically acquired infections caused by …