The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

Energy stress depletes ATP and induces cell death. Here we identify an unexpected
inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

AMPK is an evolutionarily conserved serine/threonine-protein kinase that acts as an energy
sensor in cells and plays a key role in the upregulation of catabolism and inactivation of …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

Metformin has been reported to possess antitumor activity and maintain high cytotoxic T
lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of …

Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …