The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

Nasopharyngeal carcinoma (NPC) is a prevalent tumour in southern China and southeast
Asia, particularly in the Cantonese population, where its incidence has remained high for …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

Increasing evidence has suggested that microRNAs (miRNA) play an important role in
tumorigenesis. As transcriptional regulators, altered miRNA expression may affect many …

Available targeted therapies for esophageal squamous cell carcinoma (ESCC) are limited;
thus, further genetic and epigenetic studies are needed. Recently, many long noncoding …

The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but
relatively little is known about zebrafish immune cell development and functional diversity …

Background MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are
indicated to play essential roles in spermatogenesis. However, little is known about the …

Brain-derived neurotrophic factor (BDNF) is a key positive regulator of neural plasticity,
promoting, for example, the actions of stimulant drugs of abuse such as cocaine. We …

Despite progress in treatment approaches for oral cancer, there has been only modest
improvement in patient outcomes in the past three decades. The frequent treatment failure is …

Purpose: Aberrant activation of the Wnt/β-catenin signaling pathway is associated with
multiple tumors including colorectal cancer (CRC). WNT5A is a member of the …