Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

The precise control of CRISPR-Cas9 activity is required for a number of genome
engineering technologies. Here, we report a generalizable platform that provided the first …

Abstract The hetero‐Diels–Alder reaction is one of the most powerful transformations in the
chemistry toolbox for the synthesis of aza‐and oxa‐heterocycles embodying multiple …

For two decades, diversity-oriented synthesis (DOS) has facilitated the assembly of small-
molecule libraries comprising a variety of complex molecular architectures. Here, we …

In this review, the pivotal achievements and recent advances in catalytic asymmetric aza‐
DAR reported up to 2020 are retrospectively considered and their potency for …

The Povarov reaction provides a straightforward and modular entry to 1, 2, 3, 4-
tetrahydroquinolines (THQs). Despite its importance, it was only very recently that several …

α-Imino esters are useful precursors for the synthesis of a variety of types of natural and
unnatural α-amino acid derivatives, with a wide range of biological activities. Due to the …

A highly enantioselective copper‐catalyzed alkynylation of quinolinium salts is reported. The
reaction employs StackPhos, a newly developed imidazole‐based chiral biaryl P, N ligand …

The translation of well-established molecular biology methods such as genetic coding,
selection, and DNA sequencing to combinatorial organic chemistry and compound …