Group A streptococci are model extracellular gram-positive pathogens responsible for
pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of …

Acute rheumatic fever (ARF) and its chronic sequela, rheumatic heart disease (RHD), have
become rare in most affluent populations, but remain unchecked in developing countries …

Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the
streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the α-helical coiled …

Acute rheumatic fever is a major cause of heart disease in large parts of the world, but it
remains unknown why only a small fraction of those who are infected with rheumatogenic …

Aboriginal Australians in northern Australia are subject to endemic infection with group A
streptococci, with correspondingly high rates of acute rheumatic fever and rheumatic heart …

Rheumatic heart disease is an autoimmune sequela of group A streptococcal infection.
Previous studies have established that streptococcal M protein is structurally and …

To describe the epidemiology and clinical features of Sydenham's chorea in the Aboriginal
population of northern Australia a review was conducted of 158 episodes in 108 people: 106 …

Sydenham's chorea (SC) is the neurologic expression of acute rheumatic fever (ARF).
Despite the declining incidence of ARF worldwide, it remains the most common cause of …

Acute rheumatic fever (ARF) is an autoimmune disease characterized by inflammation of
several tissues that gives rise to typical clinical characteristics including carditis/valvulitis …

Although immune responses against group A streptococci and the heart have been
correlated with antibodies and T cell responses against cardiac myosin, there is no unifying …