Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

Simple Summary Despite increasing knowledge of the biological mechanisms leading to
neoplastic transformation, the identification of various molecular targets for innovative drugs …

Acute myeloid leukemia (AML) is afflicted by a high‐mortality rate and few treatment options.
The lack of specific surface antigens severely hampers the development of targeted …

Acute myeloid leukemia (AML) arises from the cells of myeloid lineage and is the most
frequent leukemia type in adulthood accounting for about 80% of all cases. The most …

The study of marrow-resident mesodermal progenitors can provide important insight into
their role in influencing normal and aberrant hematopoiesis as occurs in acute myelogenous …

Components of the bone marrow microenvironment (BMM) have been shown to mediate the
way in which leukemia develops, progresses and responds to treatment. Increasing …

Abstract sulfur-containing amino acids have been reported to patriciate in gene regulation,
DNA methylation, protein synthesis and other physiological or pathological processes. In …

Acute lymphoblastic leukemias arising from the malignant transformation of B-cell
precursors (BCP-ALLs) are protected against chemotherapy by both intrinsic factors as well …

Acute lymphoblastic leukemia with the worst prognosis is related to minimal residual
disease. Minimal residual disease not only depends on the individual peculiarities of …

During the development of leukemia, the overgrowth of leukemia cells in the bone marrow
transforms the normal hematopoietic microenvironment into the leukemia microenvironment …