Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
The diverse metabolic roles of peripheral serotonin
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …
Insulin granule dynamics in pancreatic beta cells
P Rorsman, E Renström - Diabetologia, 2003 - Springer
Glucose-induced insulin secretion in response to a step increase in blood glucose
concentrations follows a biphasic time course consisting of a rapid and transient first phase …
concentrations follows a biphasic time course consisting of a rapid and transient first phase …
Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
Molecular biology of adenosine triphosphate-sensitive potassium channels
L Aguilar-Bryan, J Bryan - Endocrine reviews, 1999 - academic.oup.com
Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels* | Endocrine
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …
Serotonin in the gut: Blessing or a curse
S Banskota, JE Ghia, WI Khan - Biochimie, 2019 - Elsevier
Abstract Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a
neurotransmitter of the central nervous system, is seen to be predominantly secreted in the …
neurotransmitter of the central nervous system, is seen to be predominantly secreted in the …
The cell physiology of biphasic insulin secretion
Glucose-stimulated insulin secretion consists of a transient first phase followed by a
sustained second phase. Diabetes (type II) is associated with abnormalities in this release …
sustained second phase. Diabetes (type II) is associated with abnormalities in this release …
The pancreatic β-cell as a target of estrogens and xenoestrogens: implications for blood glucose homeostasis and diabetes
The estrogen receptor ERα is emerging as a key molecule involved in glucose and lipid
metabolism. The main functions of pancreatic β-cells are the biosynthesis and release of …
metabolism. The main functions of pancreatic β-cells are the biosynthesis and release of …
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
G-protein coupled receptors (GPCRs) regulate hormone secretion from islets of Langerhans,
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells
A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of
insulin secretion. In the present study we combined electron microscopy, insulin secretion …
insulin secretion. In the present study we combined electron microscopy, insulin secretion …