Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many
countries in Latin America. The important modes of transmission are by the bite of the …

Excessive expansion of adipocytes can have unhealthy consequences as excess free fatty
acids enter other tissues and cause ectopic fat deposition by resynthesizing triglycerides …

Significance: Protein disulfide isomerase (PDI) and its homologs have essential roles in the
oxidative folding and chaperone-mediated quality control of proteins in the secretory …

Chemerin is an adipocyte-secreted protein that regulates adipogenesis and the metabolic
function of mature adipocytes via activation of chemokine-like receptor 1 (CMKLR1). Herein …

Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic
steatohepatitis (NASH). Though liver‐related risk seems confined to NASH, it is currently …

Adipose tissue secretes a variety of bioactive molecules, also known as adipocytokines or
adipokines. Obesity, in particular, visceral fat accumulation, is implicated in the dysregulated …

Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone
receptors that control the transcription of specific genes by binding to regulatory DNA …

The recent advances in the understanding of adiponectin and other adipokines have
highlighted the role of adipose tissue as an active endocrine organ. One of the central …

Fat cells or adipocytes are distributed ubiquitously throughout the body and are often
regarded purely as energy stores. However, recently it has become clear that these …